The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …

Peripheral nerves and Schwann cells have to sustain constant mechanical constraints,
caused by developmental growth as well as stretches associated with movements of the …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …

Schwann cell (SC) myelination in the peripheral nervous system is essential for motor
function, and uncontrolled SC proliferation occurs in cancer. Here, we show that a dual role …

The extraordinarily thin alveolar type 1 (AT1) cell constitutes nearly the entire gas exchange
surface and allows passive diffusion of oxygen into the blood stream. Despite such an …

The Hippo signaling pathway is highly conserved from Drosophila melanogaster to
mammals and plays a crucial role in organ size control, tissue regeneration, and tumor …

Myelination is an evolutionary recent differentiation program that has been independently
acquired in vertebrates by Schwann cells in the peripheral nervous system and …

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell
(SC)-lineage-derived sarcomas. Molecular events driving SC-to-MPNST transformation are …

Schwann cells are the glial cells of the peripheral nervous system (PNS). They insulate
axons by forming a specialized extension of plasma membrane called the myelin sheath …