In the last two decades, cochlear implant surgery has evolved into a minimally invasive,
hearing preservation surgical technique. The devices used during surgery have benefited …

Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …

Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …

Despite the high incidence of inner ear disorders, there are still no dedicated medications on
the market. Drugs are currently administered by the intratympanic route, the safest way to …

Stebbins et al.(1982) suggested the guinea pig to be one of the most useful species in which
to assess the effects of noise on the inner ear based on overlap with the audible frequency …

Abstract Local glucocorticosteroid (“steroid”) therapy is widely used to treat the inner ears of
patients with Menière's disease, idiopathic sudden sensorineural hearing loss and in …

The treatment of acute hearing loss is clinically challenging due to the low efficacy of drug
delivery into the inner ear. Local intratympanic administration of dexamethasone (D) and …

Noise induces a broad spectrum of pathological injuries to the cochlea, reflecting both
mechanical damage to the delicate architecture of the structures of the organ of Corti and …

Clinically there is no effective method to prevent drug induced hearing loss in patients
undergoing chemotherapy and anti-tuberculosis therapy. In this study, we developed an …

Intratympanic (IT) gadolinium (Gd) injection is one method of delivering Gd into the inner ear
to evaluate the amount of endolymphatic hydrops (EH) using magnetic resonance imaging …