Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

In eukaryotes, almost all RNA species are processed at their 3′ ends and most mRNAs are
polyadenylated in the nucleus by canonical poly (A) polymerases. In recent years, several …

Background Alternative polyadenylation (APA) is an important mechanism of gene
expression regulation through generation of RNA isoforms with distinct 3′ termini …

A polyA (pA) tail is an essential modification added to the 3′ ends of a wide range of RNAs
at different stages of their metabolism. Here, we describe the main sources of …

RNA binding motif protein 10 (RBM10) is a regulator of alternative splicing in apoptosis and
inflammation. We discovered a splicing-independent function of RBM10 critical for the …

Emerging evidence implicates a wide range of post-transcriptional RNA modifications that
play crucial roles in fundamental biological processes including regulating gene expression …

The terminal uridylyltransferase, TUT1, builds or repairs the 3′-oligo-uridylylated tail of U6
snRNA. The 3′-oligo-uridylylated tail is the Lsm-binding site for U4/U6 di-snRNP formation …

Abstract Alternative polyadenylation (APA)-mediated 3′-untranslated region (UTR)
shortening is known to increase protein expression due to the loss of miRNA regulatory …

Aims RBM10 is a well-known RNA binding protein that regulates alternative splicing in
various disease states. We have shown a splicing-independent function of RBM10 that …

Facioscapulohumeral dystrophy (FSHD) is characterized by the contraction of the D4Z4
array located in the sub-telomeric region of the chromosome 4, leading to the aberrant …