The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Background Since its discovery, NLRP3 is almost never separated from its major role in the
protein complex it forms with ASC, NEK7 and Caspase-1, the inflammasome. This key …

Harmful algal bloom toxin microcystin has been associated with metabolic dysfunction-
associated steatotic liver disease (MASLD) progression and hepatocellular carcinoma …

Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes
in cancer patients. Before the development of organ-specific metastasis, the formation of a …

Acute lung injury (ALI) is an acute infectious diseases caused by a variety of factors. The
function of TTC4 in sepsis-induced lung injury remains largely unknown. This study aimed to …

Inflammasomes are multimeric protein complexes, sensors of intracellular danger signals,
and crucial components of the innate immune system, with the NLRP3 inflammasome being …

Abstract Heat shock protein 70 (HSP70) is a highly conserved protein functioning as a
“molecular chaperone”, which is integral to protein folding and maturation. In addition to its …

Myeloid cells are increasingly being recognized as central players orchestrating or
suppressing antitumor immune responses. With the advent of high-resolution analytical …

Background Although immunotherapy has been considered as a potent strategy for lung
adenocarcinoma (LUAD), only a small part of patients was served as potentially clinical …

Bone metastasis (BM) is a frequent complication associated with advanced cancer that
significantly increases patient mortality. Myeloid-derived suppressor cells (MDSCs) play a …