Lysosomal ion channels: what are they good for and are they druggable targets?
E Riederer, C Cang, D Ren - Annual Review of Pharmacology …, 2023 - annualreviews.org
Lysosomes play fundamental roles in material digestion, cellular clearance, recycling,
exocytosis, wound repair, Ca2+ signaling, nutrient signaling, and gene expression …
exocytosis, wound repair, Ca2+ signaling, nutrient signaling, and gene expression …
Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?
An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
The molecular heterogeneity of store-operated Ca2+ entry in vascular endothelial cells: the different roles of Orai1 and TRPC1/TRPC4 channels in the transition from …
F Moccia, V Brunetti, A Perna, G Guerra… - International journal of …, 2023 - mdpi.com
Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
Nanotechnology applications of flavonoids for viral diseases
Recent years have witnessed the emergence of several viral diseases, including various
zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory …
zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory …
Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors
A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2023 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …
The emerging role of N-Methyl-D-Aspartate (NMDA) receptors in the cardiovascular system: Physiological implications, pathological consequences, and therapeutic …
T Soda, V Brunetti, R Berra-Romani… - International journal of …, 2023 - mdpi.com
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels that are activated
by the neurotransmitter glutamate, mediate the slow component of excitatory …
by the neurotransmitter glutamate, mediate the slow component of excitatory …
Allyl Isothiocianate Induces Ca2+ Signals and Nitric Oxide Release by Inducing Reactive Oxygen Species Production in the Human Cerebrovascular Endothelial Cell …
R Berra-Romani, V Brunetti, G Pellavio, T Soda… - Cells, 2023 - mdpi.com
Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …
human brain both under basal conditions and in response to somatosensory stimulation. An …
Intracellular Ca2+ signalling: unexpected new roles for the usual suspect
Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain …
The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-d-aspartate (NMDA)
receptors (NMDARs) to mediate extracellular Ca 2+ entry and stimulate neuronal nitric oxide …
receptors (NMDARs) to mediate extracellular Ca 2+ entry and stimulate neuronal nitric oxide …
GABAA and GABAB Receptors Mediate GABA-Induced Intracellular Ca2+ Signals in Human Brain Microvascular Endothelial Cells
Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …