The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine
function of an organism, to result in adverse effects on growth and development …

Next generation risk assessment (NGRA) is an exposure-led, hypothesis-driven approach
that has the potential to support animal-free safety decision-making. However, significant …

Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …

Use of molecular data in human and ecological health risk assessments of industrial
chemicals and agrochemicals has been anticipated by the scientific community for many …

Omics methodologies are widely used in toxicological research to understand modes and
mechanisms of toxicity. Increasingly, these methodologies are being applied to questions of …

Abstract The Toxicology Forum convened an international state-of-the-science workshop
Assessing Chemical Carcinogenicity: Hazard Identification, Classification, and Risk …

Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite
chemical evaluation for human health risk assessment. In this study, we combined the high …

Transcriptomics dose–response analysis (TDRA) has emerged as a promising approach for
integrating toxicogenomics data into a risk assessment context; however, variability and …

This work estimates benchmarks for new approach method (NAM) performance in predicting
organ-level effects in repeat dose studies of adult animals based on variability in replicate …