Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
Cannabinoids and the expanded endocannabinoid system in neurological disorders
L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …
Ion channels in cancer: are cancer hallmarks oncochannelopathies?
N Prevarskaya, R Skryma, Y Shuba - Physiological reviews, 2018 - journals.physiology.org
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …
all cancer cell genotypes generally translate into several common pathophysiological …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
[HTML][HTML] The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review
L Li, C Chen, C Chiang, T Xiao, Y Chen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …
transmembrane protein that can be activated by various physical and chemical stimuli and is …
Programming of neural cells by (endo) cannabinoids: from physiological rules to emerging therapies
M Maccarrone, M Guzmán, K Mackie… - Nature Reviews …, 2014 - nature.com
Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …
important roles in neuronal and glial development. Recent experimental evidence suggests …
Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?
N Prevarskaya, H Ouadid-Ahidouch… - … of the Royal …, 2014 - royalsocietypublishing.org
Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …
migration. Calcium ions are central to these phenomena, serving as major signalling agents …
Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions
YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
[HTML][HTML] Ion channels in the regulation of apoptosis
A Kondratskyi, K Kondratska, R Skryma… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism
utilized by multicellular organisms for disposal of cells that are no longer needed or …
utilized by multicellular organisms for disposal of cells that are no longer needed or …
[HTML][HTML] The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies
T Zhong, W Zhang, H Guo, X Pan, X Chen, Q He… - … Pharmaceutica Sinica B, 2022 - Elsevier
Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …
permeable channels, and those relevant transmembrane and intracellular TRP channels …