Towards genetic dissection of skeletal class III malocclusion: a review of genetic variations underlying the phenotype in humans and future directions

O Zohud, IM Lone, K Midlej, A Obaida… - Journal of Clinical …, 2023 - mdpi.com
Introduction: Skeletal abnormalities and malocclusions have varied features that impact
populations globally, impairing aesthetics and lowering life quality. The prevalence of the …

Dissecting the complexity of skeletal-malocclusion-associated phenotypes: mouse for the rescue

IM Lone, O Zohud, A Nashef, C Kirschneck… - International Journal of …, 2023 - mdpi.com
Skeletal deformities and malocclusions being heterogeneous traits, affect populations
worldwide, resulting in compromised esthetics and function and reduced quality of life …

Comprehensive deciphering the complexity of the deep bite: insight from animal model to human subjects

N Watted, IM Lone, O Zohud, K Midlej, P Proff… - Journal of Personalized …, 2023 - mdpi.com
Deep bite is a malocclusion phenotype, defined as the misalignment in the vertical
dimension of teeth and jaws and characterized by excessive overlap of the upper front teeth …

Narrating the genetic landscape of human class I occlusion: a perspective-infused review

IM Lone, O Zohud, K Midlej, O Awadi… - Journal of Personalized …, 2023 - mdpi.com
This review examines a prevalent condition with multifaceted etiology encompassing
genetic, environmental, and oral behavioral factors. It stands as a significant ailment …

HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements

M Mielcarek, D Zielonka, A Carnemolla… - Frontiers in cellular …, 2015 - frontiersin.org
For the past decade protein acetylation has been shown to be a crucial post-transcriptional
modification involved in the regulation of protein functions. Histone acetyltransferases …

Genetic factors involved in mandibular prognathism

A Doraczynska-Kowalik, KH Nelke… - Journal of …, 2017 - journals.lww.com
Mandibular prognathism is defined as an abnormal forward projection of the mandible
beyond the standard relation to the cranial base and it is usually categorized as both a …

Genes and pathways associated with skeletal sagittal malocclusions: a systematic review

E Gershater, C Li, P Ha, CH Chung, N Tanna… - International Journal of …, 2021 - mdpi.com
Skeletal class II and III malocclusions are craniofacial disorders that negatively impact
people's quality of life worldwide. Unfortunately, the growth patterns of skeletal …

Anterior open bite malocclusion: from clinical treatment strategies towards the dissection of the genetic bases of the disease using human and collaborative cross mice …

IM Lone, O Zohud, K Midlej, E Paddenberg… - Journal of Personalized …, 2023 - mdpi.com
Anterior open bite malocclusion is a complex dental condition characterized by a lack of
contact or overlap between the upper and lower front teeth. It can lead to difficulties with …

Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns

A Cunha, P Nelson-Filho, GA Marañón-Vásquez… - Archives of Oral …, 2019 - Elsevier
Objective This study aimed to evaluate the association of genetic variants inACTN3 and
MYO1H with craniofacial skeletal patterns in Brazilians. Design This cross-sectional study …

[HTML][HTML] Masticatory muscle function affects the pathological conditions of dentofacial deformities

T Yamada, G Sugiyama, Y Mori - Japanese Dental Science Review, 2020 - Elsevier
The causes of dentofacial deformities include various known syndromes, genetics,
environmental and neuromuscular factors, trauma, and tumors. Above all, the functional …