Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

P Kubatka, A Mazurakova, M Samec, L Koklesova… - Epma Journal, 2021 - Springer
Inflammation is an essential pillar of the immune defense. On the other hand, chronic
inflammation is considered a hallmark of cancer initiation and progression. Chronic …

Skin photo-protection with phytochemicals against photo-oxidative stress, photo-carcinogenesis, signal transduction pathways and extracellular matrix remodeling …

C Garg, H Sharma, M Garg - Ageing research reviews, 2020 - Elsevier
Excessive exposure of skin to UV radiation triggers the generation of oxidative stress,
inflammation, immunosuppression, apoptosis, matrix-metalloproteases production, and DNA …

Flavonoids present in propolis in the battle against photoaging and psoriasis

CR Rivera-Yañez, PA Ruiz-Hurtado… - Antioxidants, 2021 - mdpi.com
The skin is the main external organ. It protects against different types of potentially harmful
agents, such as pathogens, or physical factors, such as radiation. Skin disorders are very …

Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review

A Ahmadi, Z Mortazavi, S Mehri… - … Archives of Pharmacology, 2022 - Springer
Scutellaria baicalensis (SB), also known as the Chinese skullcap, has a long history of being
used in Chinese medicine to treat a variety of conditions ranging from microbial infections to …

Immunological regulatory effect of flavonoid baicalin on innate immune toll-like receptors

M Jiang, Z Li, G Zhu - Pharmacological research, 2020 - Elsevier
As an essential component of the innate immune system, Toll-like receptors (TLRs) are a
family of well-recognized ligand-binding receptors found in various organisms and initiate …

Baicalin ameliorates Mycoplasma gallisepticum-induced lung inflammation in chicken by inhibiting TLR6-mediated NF-κB signalling

M Zou, L Yang, L Niu, Y Zhao, Y Sun, Y Fu… - British Poultry …, 2021 - Taylor & Francis
Mycoplasma gallisepticum (MG) causes severe lung inflammation and cell damage by
activating toll-like receptor (TLR) signalling, the nuclear factor-kappaB (NF-κ B) pathway and …

Study on multiple fingerprint profiles control and quantitative analysis of multi-components by single marker method combined with chemometrics based on Yankening …

X Wang, X Liu, J Wang, G Wang, Y Zhang, L Lan… - … Acta Part A: Molecular …, 2021 - Elsevier
In this study, we explored the quality consistent evaluation method of Yankening Tablets
(YKNT) from different manufacturers by using multiple fingerprint profiles, including dual …

Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a …

A Ahmadi, Z Mortazavi, S Mehri… - DARU Journal of …, 2022 - Springer
Objectives Scutellaria baicalensis (SB) has been traditionally used to combat a variety of
conditions ranging from ischemic heart disease to cancer. The protective effects of SB are …

Screening of benzophenone ultraviolet absorbers with high-efficiency light absorption capacity, low-permeability and low-toxicity by 3D-QSAR model

J Xiao, Y Li - Journal of Molecular Liquids, 2022 - Elsevier
In this study, the synthetical index method was used to calculate the comprehensive effect
value (CV) of ultraviolet (UV) absorption capacity, skin permeability, and planarian toxicity of …

TLR4 in skin cancer: From molecular mechanisms to clinical interventions

SE Dickinson, GT Wondrak - Molecular carcinogenesis, 2019 - Wiley Online Library
The health and economic burden imposed by skin cancer is substantial, creating an urgent
need for the development of improved molecular strategies for its prevention and treatment …