[HTML][HTML] The role of vaccines in combatting antimicrobial resistance

F Micoli, F Bagnoli, R Rappuoli, D Serruto - Nature Reviews …, 2021 - nature.com
The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives

JE Choby, J Howard‐Anderson… - Journal of internal …, 2020 - Wiley Online Library
Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global
pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing …

[HTML][HTML] Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae

RM Martin, MA Bachman - Frontiers in cellular and infection …, 2018 - frontiersin.org
Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

[HTML][HTML] Virulence Factors in Hypervirulent Klebsiella pneumoniae

J Zhu, T Wang, L Chen, H Du - Frontiers in microbiology, 2021 - frontiersin.org
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the
Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae …

Kaptive 2.0: updated capsule and lipopolysaccharide locus typing for the Klebsiella pneumoniae species complex

MMC Lam, RR Wick, LM Judd, KE Holt… - Microbial …, 2022 - microbiologyresearch.org
The outer polysaccharide capsule and lipopolysaccharide (LPS) antigens are key targets for
novel control strategies targeting Klebsiella pneumoniae and related taxa from the K …

[HTML][HTML] Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms

CR Lee, JH Lee, KS Park, JH Jeon, YB Kim… - Frontiers in cellular …, 2017 - frontiersin.org
Klebsiella pneumoniae is one of the most clinically relevant species in immunocompromised
individuals responsible for community-acquired and nosocomial infections, including …

[HTML][HTML] Diversity and function of phage encoded depolymerases

LE Knecht, M Veljkovic, L Fieseler - Frontiers in microbiology, 2020 - frontiersin.org
Bacteriophages of the Podoviridae family often exhibit so-called depolymerases as
structural components of the virion. These enzymes appear as tail spike proteins (TSPs) …

[HTML][HTML] Identification of Klebsiella capsule synthesis loci from whole genome data

KL Wyres, RR Wick, C Gorrie, A Jenney… - Microbial …, 2016 - microbiologyresearch.org
Klebsiella pneumoniae is a growing cause of healthcare-associated infections for which
multi-drug resistance is a concern. Its polysaccharide capsule is a major virulence …