Zebrafish larvae as a behavioral model in neuropharmacology

RM Basnet, D Zizioli, S Taweedet, D Finazzi, M Memo - Biomedicines, 2019 - mdpi.com
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …

Zebrafish models in neuropsychopharmacology and CNS drug discovery

KM Khan, AD Collier, DA Meshalkina… - British journal of …, 2017 - Wiley Online Library
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …

Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS

S Gaballah, A Swank, JR Sobus… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Per-and polyfluoroalkyl substances (PFAS) are a diverse class of industrial
chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is …

Enhanced uptake of BPA in the presence of nanoplastics can lead to neurotoxic effects in adult zebrafish

Q Chen, D Yin, Y Jia, S Schiwy, J Legradi… - Science of the Total …, 2017 - Elsevier
Plastic particles have been proven to be abundant in the aquatic environment, raising
concerns about their potential toxic effects. In the present study, we determined the …

The potential for adverse effects in fish exposed to antidepressants in the aquatic environment

SL Gould, MJ Winter, WHJ Norton… - … Science & Technology, 2021 - ACS Publications
Antidepressants are one of the most commonly prescribed pharmaceutical classes for the
treatment of psychiatric conditions. They act via modulation of brain monoaminergic …

Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae

Q Shi, M Wang, F Shi, L Yang, Y Guo, C Feng, J Liu… - Aquatic Toxicology, 2018 - Elsevier
Triphenyl phosphate (TPhP), a typical organophosphate ester, is frequently detected in the
environment and biota samples. It has been implicated as a neurotoxin as its structure is …

Bioconcentration and transfer of the organophorous flame retardant 1, 3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental …

Q Wang, NLS Lai, X Wang, Y Guo… - … science & technology, 2015 - ACS Publications
Organophosphate flame retardants are emerging environmental contaminants, although
knowledge of their health risks is limited. Here, thyroid hormone homeostasis and neuronal …

Multiview behavior and neurotransmitter analysis of zebrafish dyskinesia induced by 6PPD and its metabolites

J Ji, J Huang, N Cao, X Hao, Y Wu, Y Ma, D An… - Science of The Total …, 2022 - Elsevier
The typical tire manufacturing additive 6PPD, its metabolites 6PPDQ and 4-Hydroxy should
be monitored because of their ubiquitous presence in the environment and the high toxicity …

Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders: a systematic review

RL Vaz, TF Outeiro, JJ Ferreira - Frontiers in neurology, 2018 - frontiersin.org
Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the
hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's …

Effects of ibuprofen, diclofenac and paracetamol on hatch and motor behavior in developing zebrafish (Danio rerio)

L Xia, L Zheng, JL Zhou - Chemosphere, 2017 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) which are widely used as pain relief
medicines are causing increasing environmental concern due to their incomplete removal in …