Mitochondria play many important biological roles, including ATP production, lipid
biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an …

Halogenated organic compounds are pervasive in natural and built environments. Despite
restrictions on the production of many of these compounds in most parts of the world through …

Interfaces between organelles are emerging as critical platforms for many biological
responses in eukaryotic cells. In yeast, the ERMES complex is an endoplasmic reticulum …

Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …

Regulation of gene expression drives protein interactions that govern synaptic wiring and
neuronal activity. The resulting coordinated activity among neuronal populations supports …

This article highlights specific features of biological neurons and their dendritic trees, whose
adoption may help advance artificial neural networks used in various machine learning …

The active properties of dendrites can support local nonlinear operations, but previous
imaging and electrophysiological measurements have produced conflicting views regarding …

The structural organization of excitatory inputs supporting spike-timing-dependent plasticity
(STDP) remains unknown. We performed a spine STDP protocol using two-photon (2P) …

Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic
homeostasis hypothesis suggests that synaptic connections are strengthened during wake …

In the study of memory engrams, synaptic memory allocation is a newly emerged theme that
focuses on how specific synapses are engaged in the storage of a given memory …