Cholangiocyte pathobiology

JM Banales, RC Huebert, T Karlsen… - Nature Reviews …, 2019 - nature.com
Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

Primary biliary cholangitis: pathogenesis and therapeutic opportunities

AF Gulamhusein, GM Hirschfield - Nature Reviews Gastroenterology & …, 2020 - nature.com
Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

[HTML][HTML] Primary sclerosing cholangitis–a comprehensive review

TH Karlsen, T Folseraas, D Thorburn, M Vesterhus - Journal of hepatology, 2017 - Elsevier
Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and …

[HTML][HTML] Liver sinusoidal endothelial cells—gatekeepers of hepatic immunity

S Shetty, PF Lalor, DH Adams - Nature reviews Gastroenterology & …, 2018 - nature.com
Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

Cytokines and Chemokines in Mycobacterium tuberculosis Infection

R Domingo-Gonzalez, O Prince, A Cooper… - Microbiology …, 2016 - Am Soc Microbiol
Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

The immune niche of the liver

ML Cheng, D Nakib, CT Perciani… - Clinical …, 2021 - portlandpress.com
The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

Roles for chemokines in liver disease

F Marra, F Tacke - Gastroenterology, 2014 - Elsevier
Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

[HTML][HTML] The immunological basis of liver allograft rejection

V Ronca, G Wootton, C Milani, O Cain - Frontiers in immunology, 2020 - frontiersin.org
Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …

CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner

JE Ussher, M Bilton, E Attwod… - European journal of …, 2014 - Wiley Online Library
CD 161++ CD 8+ T cells represent a novel subset that is dominated in adult peripheral
blood by mucosal‐associated invariant T (MAIT) cells, as defined by the expression of a …

[HTML][HTML] International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

HJ Cordell, Y Han, GF Mells, Y Li… - Nature …, 2015 - nature.com
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective
immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data …