[HTML][HTML] The different autophagy degradation pathways and neurodegeneration
A Fleming, M Bourdenx, M Fujimaki, C Karabiyik… - Neuron, 2022 - cell.com
The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …
leucine zipper transcription factors, is an established central regulator of the …
Compromised autophagy and neurodegenerative diseases
FM Menzies, A Fleming, DC Rubinsztein - Nature Reviews …, 2015 - nature.com
Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …
Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease
DJ Colacurcio, RA Nixon - Ageing research reviews, 2016 - Elsevier
Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …
The autophagy–lysosomal pathway in neurodegeneration: a TFEB perspective
H Martini-Stoica, Y Xu, A Ballabio, H Zheng - Trends in neurosciences, 2016 - cell.com
The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …
Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases
Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …
Presenilin 1 maintains lysosomal Ca2+ homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification
JH Lee, MK McBrayer, DM Wolfe, LJ Haslett, A Kumar… - Cell reports, 2015 - cell.com
Summary Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …
Targeting autophagy for the treatment of Alzheimer's disease: challenges and opportunities
J Liu, L Li - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia which characterized by a
progressive loss of memory and cognitive function due to degeneration of synapses and …
progressive loss of memory and cognitive function due to degeneration of synapses and …
Role of lysosomes in physiological activities, diseases, and therapy
Z Zhang, P Yue, T Lu, Y Wang, Y Wei, X Wei - Journal of hematology & …, 2021 - Springer
Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application …
S Sarkar - Biochemical Society Transactions, 2013 - portlandpress.com
Autophagy is an intracellular degradation pathway essential for cellular and energy
homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles …
homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles …