Learning and memory is widely believed to result from changes in connectivity within
neuronal circuits due to synaptic plasticity. Work over the past two decades has shown that …

Neurofilaments are uniquely complex among classes of intermediate filaments in being
composed of four subunits (NFL, NFM, NFH and alpha-internexin in the CNS) that differ in …

Glutamate-gated AMPA receptors mediate the fast component of excitatory signal
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …

Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed disorder of
school-age children. Although genetic and brain-imaging studies suggest a contribution of …

Neuronal development relies on a highly choreographed progression of dynamic cellular
processes by which newborn neurons migrate, extend axons and dendrites, innervate their …

The activation of neuronal plasma membrane Ca2+ channels stimulates many intracellular
responses. Scaffolding proteins can preferentially couple specific Ca2+ channels to distinct …

Malignant gliomas including Glioblastoma (GBM) are characterized by extensive diffuse
tumor cell infiltration throughout the brain, which represents a major challenge in clinical …

Voltage-gated Cav1. 2 and Cav1. 3 (L-type) Ca2+ channels regulate neuronal excitability,
synaptic plasticity, and learning and memory. Densin-180 (densin) is an excitatory synaptic …

The development of selectively bred high and low alcohol‐preferring mice (HAP and LAP,
respectively) has allowed for an assessment of the polygenetic risk for pathological alcohol …

Protein-protein interactions are thought to modulate the efficiency and specificity of Ca
2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) signaling in specific subcellular …