Methotrexate: a gold standard for treatment of rheumatoid arthritis

CG Shinde, MP Venkatesh, TMP Kumar… - Journal of pain & …, 2014 - Taylor & Francis
Rheumatoid arthritis (RA) is a painful, debilitating disease characterized by inflammation of
the joints, with the proliferation of the synovium and the progressive erosion of cartilage and …

The synthesis of methotrexate-loaded F127 microemulsions and their in vivo toxicity in a rat model

A Rahdar, MR Hajinezhad, S Nasri, H Beyzaei… - Journal of Molecular …, 2020 - Elsevier
Methotrexate (MTX) has been often formulated as nano and micro-emulsions, nominally to
address its poor solubility and off-target effects. Nanoformulated MTX is universally reported …

[HTML][HTML] Role of clove oil in solvent exchange-induced doxycycline hyclate-loaded Eudragit RS in situ forming gel

T Phaechamud, SM Thurein, T Chantadee - asian journal of …, 2018 - Elsevier
Solvent exchange induced in situ forming gel (ISG) is the promising drug delivery system for
periodontitis treatment owing to the prospect of maintaining an effective high drug level in …

Tolmetin sodium-loaded thermosensitive mucoadhesive liquid suppositories for rectal delivery; strategy to overcome oral delivery drawbacks

MA Akl, HR Ismael, FI Abd Allah… - Drug development …, 2019 - Taylor & Francis
Tolmetin sodium (TS) is a nonsteroidal anti-inflammatory drug (NSAID) indicated for
treatment of musculoskeletal issues. As other NSAID, TS displays a marked side effects on …

SLN based alendronate in situ gel as an implantable drug delivery system–A full factorial design approach

T Das, MP Venkatesh, TMP Kumar, M Koland - Journal of Drug Delivery …, 2020 - Elsevier
Osteoporosis is a condition in which the body loses bone density and turns weak. Solid Lipid
Nanoparticles (SLN) are potential, biocompatible and efficient nanocomposite system, which …

[HTML][HTML] Targeted drug delivery of Methotrexate in situ gels for the treatment of Rheumatoid Arthritis

MP Venkatesh, TP Kumar, DR Pai - Saudi Pharmaceutical Journal, 2020 - Elsevier
Rheumatoid arthritis (RA) is considered a debilitating disease that increases the risk of
significant morbidity and premature mortality. To circumvent drug-related toxicity and …

Current developments in therapeutic drug targeting for the management of rheumatoid arthritis: an emerging paradigm

DR Pai, VM Prakash, TMP Kumar - Critical Reviews™ in …, 2019 - dl.begellhouse.com
Rheumatoid arthritis (RA) is a debilitating condition that results in impairment of joints and
ligaments and thus constrained mobility and decreased array of movement. It is a broad …

Impact of Pluronics of different structure on pharmacologically relevant properties of sulfasalazine and methotrexate

T Volkova, R Kumeev, N Kochkina… - Journal of Molecular …, 2019 - Elsevier
The work was focused on comprehensive evaluation and comparison of the effect of
Pluronics of different architecture on the pharmacologically relevant properties of …

Nanostructured lipid carrier-based smart gel: a delivery platform for intra-articular therapeutics

C Shinde, MP Venkatesh, T Pramod Kumar… - Autoimmunity, 2021 - Taylor & Francis
The promising potential of nano-structured lipid carrier (NLC) polymeric gel of CUR as an
effective treatment for rheumatoid arthritis by intra-articular route of administration was …

[PDF][PDF] Injectable in situ gel of methotrexate for rheumatoid arthritis: Development, in vitro and in vivo evaluation

T Das, VM Prakash, PKT Math - Journal of Applied Pharmaceutical …, 2019 - japsonline.com
The aim of the research study was to formulate a novel, biodegradable, injectable in situ gel
system of Methotrexate (MTX) in the management of rheumatoid arthritis (RA). Varying …