Gut microbiota and short chain fatty acids: implications in glucose homeostasis

P Portincasa, L Bonfrate, M Vacca… - International journal of …, 2022 - mdpi.com
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with …

Intestinal barrier and permeability in health, obesity and NAFLD

P Portincasa, L Bonfrate, M Khalil, MD Angelis… - Biomedicines, 2021 - mdpi.com
The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

R Singhal, YM Shah - Journal of Biological Chemistry, 2020 - ASBMB
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Regulation of immune cell function by short‐chain fatty acids

R Corrêa‐Oliveira, JL Fachi, A Vieira… - Clinical & …, 2016 - Wiley Online Library
Short‐chain fatty acids (SCFAs) are bacterial fermentation products, which are chemically
composed by a carboxylic acid moiety and a small hydrocarbon chain. Among them, acetic …

Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor–dependent repression of claudin-2

L Zheng, CJ Kelly, KD Battista, R Schaefer… - The Journal of …, 2017 - journals.aai.org
Commensal interactions between the enteric microbiota and distal intestine play important
roles in regulating human health. Short-chain fatty acids (SCFAs), such as butyrate …

Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation

V Garcia‐Hernandez, M Quiros… - Annals of the New York …, 2017 - Wiley Online Library
The intestinal epithelium forms a highly dynamic and selective barrier that controls
absorption of fluid and solutes while restricting pathogen access to underlying tissues …

Intestinal permeability, inflammation and the role of nutrients

R Farré, M Fiorani, S Abdu Rahiman, G Matteoli - Nutrients, 2020 - mdpi.com
The interaction between host and external environment mainly occurs in the gastrointestinal
tract, where the mucosal barrier has a critical role in many physiologic functions ranging …

[HTML][HTML] Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

AR Bourgonje, D Kloska, A Grochot-Przęczek… - Redox Biology, 2023 - Elsevier
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia

L Zheng, CJ Kelly, SP Colgan - American Journal of …, 2015 - journals.physiology.org
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …

Effects of dietary components on intestinal permeability in health and disease

K Khoshbin, M Camilleri - American Journal of Physiology …, 2020 - journals.physiology.org
Altered intestinal permeability plays a role in many pathological conditions. Intestinal
permeability is a component of the intestinal barrier. This barrier is a dynamic interface …