Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture,
vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute …

Cancer-associated fibroblasts (CAFs) are major components of the carcinoma
microenvironment that promote tumor progression. However, the mechanisms by which …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into
biochemical signals that regulate gene expression and cell behavior via specialized …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

This review discusses recent advances in our understanding of the role filopodia and
filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

With ageing, bone tissue undergoes significant compositional, architectural and metabolic
alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent bone …

Solid tumors are characterized by an abnormal stroma that contributes to the development of
biomechanical abnormalities in the tumor microenvironment. In particular, these …