Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Prostaglandin E2 and cancer: insight into tumor progression and immunity

F Finetti, C Travelli, J Ercoli, G Colombo, E Buoso… - Biology, 2020 - mdpi.com
Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

Ketogenic diet in cancer prevention and therapy: molecular targets and therapeutic opportunities

WH Talib, AI Mahmod, A Kamal, HM Rashid… - Current issues in …, 2021 - mdpi.com
Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …

Immune regulatory processes of the tumor microenvironment under malignant conditions

K Pansy, B Uhl, J Krstic, M Szmyra, K Fechter… - International journal of …, 2021 - mdpi.com
The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Since immune cells represent a large fraction of the TME, they play a key role in …

Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities

SM Ryan, RM Eichenberger, R Ruscher… - PLoS …, 2020 - journals.plos.org
Parasitic helminths have coevolved with humans over millennia, intricately refining and
developing an array of mechanisms to suppress or skew the host's immune system, thereby …

[Retracted] Ferroptosis‐Related Long Noncoding RNAs as Prognostic Marker for Colon Adenocarcinoma

Y Qiu, H Li, Q Zhang, X Qiao… - Applied Bionics and …, 2022 - Wiley Online Library
Background. The incidence of colon adenocarcinoma (COAD) has been increasing over
time. Although ferroptosis and long noncoding RNAs (lncRNAs) have been extensively …

Phospholipase A2 superfamily in cancer

Z Peng, Y Chang, J Fan, W Ji, C Su - Cancer Letters, 2021 - Elsevier
Phospholipase A2 enzymes (PLA 2 s) comprise a superfamily that is generally divided into
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …

Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis

X Dai, Y Xie, M Dong - Cancer Biology & Therapy, 2022 - Taylor & Francis
Colorectal adenocarcinoma (COAD) is a prevalent malignant tumor. Cancer-associated
fibroblasts (CAFs)-derived extracellular vesicles (EVs)(CAFs-EVs) are implicated in COAD …

The role of Th17 cells in the pathogenesis and treatment of breast cancer

V Karpisheh, M Ahmadi, K Abbaszadeh-Goudarzi… - Cancer Cell …, 2022 - Springer
Breast cancer is a severe problem worldwide due to an increase in mortality and prevalence
among women. Despite early diagnostic procedures as well as advanced therapies, more …

Reprogrammed lipid metabolism and the lipid-associated hallmarks of colorectal cancer

T Salita, YH Rustam, D Mouradov, OM Sieber, GE Reid - Cancers, 2022 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate …