Background Many factors of trauma care have changed in the last decades. This review
investigated the effect of these changes on global all-cause and cause-specific mortality in …

Background Traumatic injuries are physical insults to the body that are prevalent worldwide.
Many individuals involved in accidents suffer injuries affecting a number of extremities and …

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

BACKGROUND & AIMS: Acute liver failure (ALF) is a rapidly progressive critical illness with
high mortality. Complex intensive care unit (ICU) protocols and emergency liver …

Objective: We hypothesized that after sepsis in humans, MDSCs will be persistently
increased, functionally immunosuppressive, and associated with adverse clinical outcomes …

Background Fatal trauma is one of the leading causes of death in Western industrialized
countries. The aim of the present study was to determine the preventability of traumatic …

BACKGROUND We recently proffered that a new syndrome persistent inflammation,
immunosuppression, and catabolism syndrome (PICS) has replaced late multiple-organ …

Abstract According to the World Health Organization, post-traumatic mortality rates are still
very high and show an increasing tendency. Disorders of innate immune response that may …

Background Pulmonary contusion is a major risk factor of acute respiratory distress
syndrome (ARDS) in trauma patients. As this complication may appear after a free interval of …

Trauma is the leading cause of mortality in humans below the age of 40. Patients injured by
accidents frequently suffer severe multiple trauma, which is life-threatening and leads to …