CD19-directed CAR T cells as first salvage therapy for large B-cell lymphoma: towards a rational approach

P Dreger, P Corradini, JG Gribben, B Glass… - The Lancet …, 2023 - thelancet.com
The approval of CD19-directed chimeric antigen receptor (CAR) T-cell therapies for the
second-line treatment of high-risk large B-cell lymphoma (LBCL) has greatly affected …

Integrating CAR-T cell therapy into the management of DLBCL: what we are learning

M Martino, FA Canale, G Porto, C Verduci… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Chimeric Antigen Receptor;(CAR) T cells therapies have become
part of the standard of care for patients with relapsed/refractory (R/R) diffuse large B-cell …

CNS bridging radiotherapy achieves rapid cytoreduction before CAR T-cell therapy for aggressive B-cell lymphomas

GY Cederquist, J Schefflein, SM Devlin… - Blood …, 2024 - ashpublications.org
Chimeric antigen receptor (CAR) T-cell therapy (CART) for central nervous system
lymphoma (CNSL) is a promising strategy, yet responses are frequently not durable …

Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange

L Kühne, P Knöbl, K Eller, J Thaler, WR Sperr… - Blood, 2024 - ashpublications.org
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening autoimmune
disorder caused by a disintegrin and metalloproteinase with thrombospondin type 1 motif …

Incorporating radiation with anti‐CD19 chimeric antigen receptor T‐cell therapy for relapsed/refractory non‐Hodgkin lymphoma: A multicenter consensus approach

O Saifi, SC Lester, WG Breen, WG Rule… - American journal of …, 2024 - Wiley Online Library
Anti‐CD19 chimeric antigen receptor T‐cell therapy (CART) has revolutionized the
outcomes of relapsed and/or refractory B‐cell non‐Hodgkin lymphoma. However, CART is …

[HTML][HTML] CAR-T cell therapy in large B cell lymphoma

U Testa, G Leone, E Pelosi, G Castelli… - … Journal of Hematology …, 2023 - ncbi.nlm.nih.gov
Large B-cell lymphomas (LBCLs) are among the most frequent (about 30%) non-Hodgkin's
lymphoma. Despite the aggressive behavior of these lymphomas, more than 60% of patients …

[HTML][HTML] Efficient combination of radiotherapy and CAR-T–A systematic review

W Szlasa, A Sztuder, A Kaczmar-Dybko… - Biomedicine & …, 2024 - Elsevier
Chimeric antigen receptor T (CAR-T) cell therapy, a groundbreaking immunotherapy.
However, it faces formidable challenges in treating solid tumors, grappling with issues like …

Metabolic Tumor Volume Response after Bridging Therapy Determines Chimeric Antigen Receptor T-Cell Outcomes in Large B-Cell Lymphoma

H Hubbeling, D Leithner, EA Silverman… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: Greater disease burden is a well-established predictor of poorer outcomes
following chimeric antigen receptor T-cell (CAR T) therapy. Although bridging therapy (BT) is …

Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy

X Deschenes-Simard, BD Santomasso… - Blood …, 2024 - ashpublications.org
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of patients
with relapsed or refractory hematologic malignancies, but it comes with unique toxicities …

Reappraisal of the role of radiation therapy in lymphoma treatment

L Specht - Hematological Oncology, 2023 - Wiley Online Library
Radiation therapy (RT) for lymphomas has improved dramatically with modern imaging and
treatment techniques, encompassing only the necessary volume with minimal doses to …