[PDF][PDF] Motor unit

CJ Heckman, RM Enoka - Comprehensive physiology, 2012 - drive.google.com
Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?

MC Bellingham - CNS neuroscience & therapeutics, 2011 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

You are as fast as your motor neurons: speed of recruitment and maximal discharge of motor neurons determine the maximal rate of force development in humans

A Del Vecchio, F Negro, A Holobar… - The Journal of …, 2019 - Wiley Online Library
Key points We propose and validate a method for accurately identifying the activity of
populations of motor neurons during contractions at maximal rate of force development in …

Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy

GZ Mentis, D Blivis, W Liu, E Drobac, ME Crowder… - Neuron, 2011 - cell.com
To define alterations of neuronal connectivity that occur during motor neuron degeneration,
we characterized the function and structure of spinal circuitry in spinal muscular atrophy …

Single-layer graphene modulates neuronal communication and augments membrane ion currents

NP Pampaloni, M Lottner, M Giugliano… - Nature …, 2018 - nature.com
The use of graphene-based materials to engineer sophisticated biosensing interfaces that
can adapt to the central nervous system requires a detailed understanding of how such …

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

Y Sun, KMA Yong, LG Villa-Diaz, X Zhang, W Chen… - Nature materials, 2014 - nature.com
Our understanding of the intrinsic mechanosensitive properties of human pluripotent stem
cells (hPSCs), in particular the effects that the physical microenvironment has on their …

Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion

GB Miles, R Hartley, AJ Todd… - Proceedings of the …, 2007 - National Acad Sciences
To effect movement, motoneurons must respond appropriately to motor commands. Their
responsiveness to these inputs, or excitability, is regulated by neuromodulators. Possible …

Recovery of neuronal and network excitability after spinal cord injury and implications for spasticity

JM D'amico, EG Condliffe, KJB Martins… - Frontiers in integrative …, 2014 - frontiersin.org
The state of areflexia and muscle weakness that immediately follows a spinal cord injury
(SCI) is gradually replaced by the recovery of neuronal and network excitability, leading to …

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

N Delestrée, M Manuel, C Iglesias… - The Journal of …, 2014 - Wiley Online Library
Key points Intrinsic hyperexcitability of spinal motoneurones is thought to contribute to
excitotoxicity during amyotrophic lateral sclerosis (ALS), but it has never been demonstrated …

Maximal discharge rate of motor units determines the maximal rate of force development during ballistic contractions in human

J Duchateau, S Baudry - Frontiers in human neuroscience, 2014 - frontiersin.org
The magnitude of the neural activation, and hence the force produced by a muscle, depend
on the number of motor units activated (recruitment) and the rates at which motor neurons …