The cerebellar cholinergic system belongs to the third type of afferent nerve fiber system
(after the climbing and mossy fibers), and has important modulatory effects on cerebellar …

Synaptic aging has been associated with neuronal circuit dysfunction and cognitive decline.
Reduced mitochondrial function may be an early event that compromises synaptic integrity …

Brain bioenergetic abnormalities in mood disorders were detected by neuroimaging in vivo
studies in humans. Because of the increasing importance of mitochondrial pathogenetic …

Glutamate is involved in cerebral ischemic injury, but its role has not been completely
clarified and studies are required to understand how to minimize its detrimental effects …

Proteomics is one of the commonly used techniques to explore the protein composition or
protein modification status in various healthy or diseased brain tissues in the past decades …

Subcellular fractionation by differential ultracentrifugation has allowed the study of the cell
and its organelles from a morphological, physiological, and biochemical perspective …

Differential ultracentrifugation and subcellular fractionation historically helped to study the
components of the cell, to discover new cellular organelles, and to decipher their …

Functional Proteomics is a useful technology to study the neuronal biochimism, allowing to
evaluate the metabolic changes within neuronal cells and brain tissue that may imply some …