Fetal alcohol spectrum disorders

S Popova, ME Charness, L Burd, A Crawford… - Nature reviews Disease …, 2023 - nature.com
Alcohol readily crosses the placenta and may disrupt fetal development. Harm from prenatal
alcohol exposure (PAE) is determined by the dose, pattern, timing and duration of exposure …

Alcohol and the developing brain: why neurons die and how survivors change

A Granato, B Dering - International journal of molecular sciences, 2018 - mdpi.com
The consequences of alcohol drinking during pregnancy are dramatic and usually referred
to as fetal alcohol spectrum disorders (FASD). This condition is one of the main causes of …

Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits

MR Orzabal, ER Lunde-Young, JI Ramirez… - Translational …, 2019 - Elsevier
Increasing popularity of electronic cigarettes (e-cigs), including among women of
reproductive age, is attributed to its perceived safety compared to conventional tobacco …

Vascular Effects, Potential Pathways and Mediators of Fetal Exposure to Alcohol and Cigarette Smoking during Pregnancy: A Narrative Review

TC Hartel, A Oelofse, JJA De Smidt - International Journal of …, 2023 - mdpi.com
(1) Background: Programming of atherosclerosis results in vascular structure and function
alterations, which may be attributed to fetal exposure to maternal tobacco smoking, alcohol …

Maternal circulating miRNAs contribute to negative pregnancy outcomes by altering placental transcriptome and fetal vascular dynamics

MR Pinson, AM Tseng, TE Lehman, K Chung… - Plos one, 2023 - journals.plos.org
Circulating miRNAs the in blood are promising biomarkers for predicting pregnancy
complications and adverse birth outcomes. Previous work identified 11 gestationally …

[HTML][HTML] Vascular contributions to the Neurobiological effects of prenatal Alcohol exposure

SZ Momin, JT Le, RC Miranda - Advances in drug and …, 2023 - frontierspartnerships.org
Background: Fetal alcohol spectrum disorders (FASD) are often characterized as a cluster of
brain-based disabilities. Though cardiovascular effects of prenatal alcohol exposure (PAE) …

In Vivo Administration of Phosphatidic Acid, a Direct Alcohol Target Rescues Fetal Growth Restriction and Maternal Uterine Artery Dysfunction in Rat FASD Model

JD Janeski, VD Naik, AL Carabulea, H Jiang… - Nutrients, 2024 - mdpi.com
Fetal growth restriction is a hallmark of Fetal Alcohol Syndrome (FAS) and is accompanied
by maternal uterine circulatory maladaptation. FAS is the most severe form of Fetal Alcohol …

Paeonol promotes reendothelialization after vascular injury through activation of c-Myc/VEGFR2 signaling pathway

Y Wang, Z Wang, X Wu, S Zhu, Q Guo… - Drug Design …, 2023 - Taylor & Francis
Purpose Dysfunction of endothelium is associated with multiple pathological vascular
diseases. However, how to regulate reendothelialization after vascular injury is not well …

Distribution of phosphatidylethanol in maternal and fetal compartments after chronic gestational binge alcohol exposure

V Naik, R Lunde‐Young, J Ramirez… - Alcoholism: Clinical …, 2020 - Wiley Online Library
Background Phosphatidylethanol (PEth) is a promising biomarker for gestational alcohol
exposure. Studies show PEth accumulation in maternal and fetal blood following alcohol …

Interaction of alcohol & phosphatidic acid in maternal rat uterine artery function

VD Naik, J Lee, MO Orzabal, J Ramadoss - Reproductive Toxicology, 2022 - Elsevier
Alcohol has been demonstrated to impair maternal uterine arterial adaptations in Fetal
Alcohol Spectrum Disorder (FASD) animal models. However, the exact mechanism remains …