Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Heart failure (HF) is an acute or chronic clinical syndrome that results in a decrease in
cardiac output and an increase in intracardiac pressure at rest or upon exertion. The …

Abstract Background Extracellular vesicles (EVs) are lipid-bound particles that are naturally
released from cells and mediate cell-cell communication. Integrin adhesion receptors are …

The nucleoprotein AHNAK is an unusual and somewhat mysterious scaffolding protein
characterised by its large size of approximately 700 kDa. Several aspects of this protein …

Breast cancer is currently the most common cancer and the leading cause of cancer death
among women worldwide. Advanced breast cancer is prone to metastasis, and there is …

Midkine (MK) and pleiotrophin (PTN) are two neurotrophic factors that are highly up‐
regulated in different brain regions after the administration of various drugs of abuse and in …

Background Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an
unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and …

The mortality rates of cancer patients decreased by~ 1.5% per year between 2001 and
2015, although the decrease depends on patient sex, ethnic group and type of malignancy …

Metastasis is an important cause of cancer-related death. Previous studies in our laboratory
found that pregnane alkaloids from Pachysandra terminalis had antimetastatic activity …

The P2X7 receptor (P2X7R) has been reported as a key mediator in inflammatory processes
and cancer invasion/metastasis. In this study, we report the discovery of novel P2X7R …