Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently
found in aging men. Androgens are essential for the development and differentiated function …

Prostate cancer is the most common newly diagnosed malignancy in men, and the second
most common cause of cancer-related death in the United States. The primary treatment for …

Transgenic mice expressing human insulin-like growth factor 1 (IGF-1) in basal epithelial
cells of prostate have been characterized. Transgene expression led to activation of the IGF …

Germ cell apoptosis, which occurs normally during spermatogenesis, increases after
testosterone withdrawal from the testis. The molecular mechanism by which this occurs …

Human 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is a key steroidogenic
enzyme that catalyzes the first step in the conversion of circulating dehydroepiandrosterone …

The epididymis is the site where spermatozoa are matured and stored. After orchidectomy,
this tissue loses up to 80% of its weight. In the prostate, androgen withdrawal by …

Constitutive activation of the phosphatidylinositol 3′-kinase (PI3 kinase)-Akt/protein kinase
B (PKB)“survival signaling” pathway is a likely mechanism by which many cancers become …

In the mouse, opening of the vaginal cavity to the skin is a late event, occurring around the
fifth week of life; it can be induced in sexually immature mice by β-estradiol injections. We …

Blood flow to the rat ventral prostate (VP), dorsolateral prostate (DP), and Dunning R3327
prostatic tumors was measured at different times up to 7 days after castration, using the …

The effects of stromal and hormonal environment on the immortalized but nontumorigenic
human prostatic epithelial cell line BPH-1 were investigated in an in vivo model. BPH-1 cells …