In primary sensory neocortical areas of mammals, the distribution of sensory receptors is
mapped with topographic precision and amplification in proportion to the peripheral receptor …

One approach to examining how higher sensory, motor, and cognitive faculties emerge in
the neocortex is to elucidate the underlying wiring principles of the brain during …

A dynamic interplay between intrinsic regional molecular cues and extrinsic factors from the
thalamus shape multiple features of early cortical development. It remains uncertain and …

Recent evidence demonstrates that low-frequency oscillations of intracellular calcium on
timescales of seconds to minutes drive distinct aspects of neuronal development, but the …

Selective serotonin reuptake inhibitor (SSRI)-type antidepressants are often prescribed to
depressive pregnant women for their less adverse side effects. However, growing evidences …

To assess the impact of synaptic neurotransmitter release on neural circuit development, we
analyzed barrel cortex formation after thalamic or cortical ablation of RIM1 and RIM2 …

Active zones are specialized areas of the plasma membrane in the presynaptic nerve
terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain …

Information processing in our brains depends on the exact timing of calcium (Ca2+)-
activated exocytosis of synaptic vesicles (SVs) from unique release sites embedded within …

Abstract N-methyl-D-aspartate (NMDA) type of glutamate receptors play an important role in
activity-dependent plasticity in the developing cortex. However, the physiological patterns of …

cAMP critically modulates the development of neuronal connectivity. It is involved in a wide
range of cellular processes that require independent regulation. However, our …