Bleeding of unknown cause (BUC), also known as unclassified bleeding disorders (UBD),
has been defined as a clear bleeding tendency in the presence of normal haemostatic tests …

Since its discovery more than 20 years ago, a lot has been revealed about the biochemistry
and physiological behaviour of carboxypeptidase U (CPU). Recent advances in CPU …

In more than 50% of patients with a mild-to-moderate bleeding tendency, no underlying
cause can be identified (bleeding of unknown cause, BUC). Data on parameters of …

Patients with bleeding of unknown cause (BUC) present with a variety of mild to moderate
bleeding symptoms, but no hemostatic abnormalities can be found. Hyperfibrinolysis is …

Bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion after exhaustive
evaluation of plasmatic coagulation and platelet function. This review explores the utility of …

The evaluation of patients with a bleeding tendency represents a challenge as the routinely
available tests for evaluating bleeding disorders are limited, complicating the laboratory …