The brutal toll of another viral pandemic can be blunted by investing now in research that
uncovers mechanisms of broad-based immunity so we may have vaccines and therapeutics …

Vaccine-induced immunity is expected to target the native antigens expressed by the
pathogens. Therefore, it is highly important to generate vaccine antigens that are …

Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high
capacity for rapid development. Generation of a universal influenza virus vaccine with the …

Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied
the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated …

Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
mutated continuously and newly emerging variants escape from antibody-mediated …

Infectious virus diseases, particularly coronavirus disease 2019, have posed a severe threat
to public health, whereas the developed therapeutic and prophylactic strategies are …

Despite prolific efforts to characterize the antibody response to human immunodeficiency
virus type 1 (HIV-1) and hepatitis C virus (HCV) mono-infections, the response to chronic co …

Many interactions between microbes and their hosts are driven or influenced by glycans,
whose heterogeneous and difficult to characterize structures have led to an …

A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …