The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

The development of oncoprotein-targeted anticancer drugs is an invaluable weapon in the
war against cancer. However, cancers do not give up without a fight. They may develop …

Abstract Early growth response-1 (EGR1) is a transcription factor correlated with prostate
cancer (PC) progression in a variety of contexts. For example, EGR1 levels increase in …

A deeper mechanistic understanding of tumour angiogenesis regulation is needed to
improve current anti-angiogenic therapies. Here we present evidence from systems-based …

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …

Nicotine, a major alkaloid found in tobacco, is a significant risk factor for gastric cancer. IL-8,
a pleiotropic cytokine, plays a vital role in cancer cell metastasis. The role of nicotine in IL-8 …

Ovarian cancer is a leading cause of death among women globally often characterized by
poor prognosis and aggressive tumor growth. The therapeutic outcomes of ovarian cancer …

Significance: Nuclear factor kappa B (NF-κB) is a master regulator of the inflammatory
response and represents a key regulatory node in the complex inflammatory signaling …

The role of the transcription factor NF-κB in shaping the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …

AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of
metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status …