Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

Endothelial cells that form the inner layer of blood and lymphatic vessels are important
regulators of vascular functions and centrally involved in the pathogenesis of vascular …

The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor
angiogenesis, inflammatory vascular remodeling, and vessel leakage. ANG1 is a Tie2 …

TIE2 is a receptor-like tyrosine kinase expressed almost exclusively in endothelial cells and
early hemopoietic cells and required for the normal development of vascular structures …

Abstract TIE-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically
expressed in developing vascular endothelial cells. To study the functions of Tie-1 and Tie-2 …

The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and
lymphatic vessel development, and vascular permeability, inflammation, angiogenic …

Glioblastomas are highly vascular tumors which overexpress the angiogenesis factor
vascular endothelial growth factor (VEGF). VEGF and its receptors, VEGF-R1 and VEGF-R2 …

Vascular endothelial cells are critical for the development and function of the mammalian
circulatory system. We have analyzed the role of the endothelial cell‐specific receptor …

EVELOPMENTAL growth, the remodeling and regeneration of adult tissues as well as solid
tumor growth, can only occur accompanied by blood vessel formation. Angioblasts and …

Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated,
and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by …