Azoospermia affects 1% of men, and it can be due to:(i) hypothalamic-pituitary
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …

It is estimated that one in 100 men have azoospermia, the complete lack of sperm in the
ejaculate. Currently,~ 20% of azoospermia cases remain idiopathic. Non-obstructive …

Mitophagy is a major quality control pathway that removes unwanted or dysfunctional
mitochondria and plays an essential role in vascular health. Here we show that MCM8 …

Abstract The minichromosome maintenance (MCM) 8/9 helicase is a AAA+ complex
involved in DNA replication-associated repair. Despite high sequence homology to the …

Analysis of cancer mutagenic signatures provides information about the origin of mutations
and can inform the use of clinical therapies, including immunotherapy. In particular …

Homologous recombination (HR) mediates the error-free repair of DNA double-strand
breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold …

We performed a detailed cancer VS normal analysis to explore the expression and
prognostic value of minichromosome maintenance (MCM) proteinsin human sarcoma. The …

Replication forks restarted by homologous recombination are error prone and replicate both
strands semi-conservatively using Pol δ. Here, we use polymerase usage sequencing to …

Our genome bears tens of thousands of harms and devastations per day; In this regard,
numerous sophisticated and complicated mechanisms are embedded by our cells in …

Accurate and integral cellular DNA replication is modulated by multiple replication‐
associated proteins, which is fundamental to preserve genome stability. Furthermore …