The small airways are defined as those less than 2 mm in diameter. They are a major site of
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …

The incidence of asthma is increasing worldwide, but morbidity and mortality are decreasing
because of improvements in medical care. Although the incidence of severe perioperative …

RATIONALE AND OBJECTIVES: Although multiple detector computed tomography (MDCT)
and hyperpolarized gas magnetic resonance imaging (HP MRI) have demonstrated ability to …

The purpose of this work was to explore the use of image registration-derived variables
associated with computed tomographic (CT) imaging of the lung acquired at multiple …

Rationale: Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled
methacholine, which computer simulations of lung impedance suggest is due to enhanced …

Chronic obstructive pulmonary disease (COPD) involves a complex interaction of structural
and functional abnormalities. The two have long been studied in isolation. However …

Rationale: In the normal lung, breathing and deep inspirations potently antagonize
bronchoconstriction, but in the asthmatic lung this salutary effect is substantially attenuated …

The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that
helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary …

Already established as a'classic'in the field, Clinical Tests of Respiratory Function presents
an authoritative yet accessible account of this complex area, fusing the basic principles of …

Rationale: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is
associated with disease severity in patients with chronic obstructive pulmonary disease …