Effects of chronic fluoxetine treatment on anxiety-and depressive-like behaviors in adolescent rodents–systematic review and meta-analysis

J Kryst, I Majcher-Maślanka, A Chocyk - Pharmacological Reports, 2022 - Springer
Background Drugs prescribed for psychiatric disorders in adolescence should be studied
very extensively since they can affect developing and thus highly plastic brain differently …

Chlordiazepoxide reduces anxiety-like behavior in the adolescent mouse elevated plus maze: a pharmacological validation study

A Themann, M Rodriguez, J Reyes-Arce… - Pharmacology …, 2024 - Elsevier
This report evaluates the effects of chlordiazepoxide, a benzodiazepine commonly
prescribed to manage anxiety-related disorders in adolescent/pediatric populations, on …

[HTML][HTML] Sex-Specific Alterations in Spatial Memory and Hippocampal AKT-mTOR Signaling in Adult Mice Pre-exposed to Ketamine and/or Psychological Stress …

I Garcia-Carachure, O Lira, A Themann… - … psychiatry global open …, 2024 - Elsevier
Background Ketamine (KET) is administered to manage major depression in adolescent
patients. However, the long-term effects of juvenile KET exposure on memory-related tasks …

Acute and long‐lasting effects of adolescent fluoxetine exposure on feeding behavior in Sprague–Dawley rats

AL Castro, M Frankot, TH Moran… - Developmental …, 2022 - Wiley Online Library
The antidepressant medication fluoxetine (FLX) is frequently prescribed for the management
of mood‐related illnesses in the adolescent population—yet its long‐term neurobehavioral …

Autophagy induction and accumulation of phosphorylated tau in the hippocampus and prefrontal cortex of adult C57BL/6 mice subjected to adolescent fluoxetine …

JA Sierra-Fonseca, M Rodriguez… - Journal of …, 2021 - content.iospress.com
Background: Fluoxetine (FLX) represents the antidepressant of choice for the management
of pediatric mood-related illnesses. Accumulating preclinical evidence suggests that …

Effect of early-life stress or fluoxetine exposure on later-life conditioned taste aversion learning in Sprague-Dawley rats

VA Gutierrez, AA Carrillo, GJ Boersma… - Neuroscience …, 2022 - Elsevier
In rodents, early-life exposure to environmental stress or antidepressant medication
treatment has been shown to induce similar long-term consequences on memory-and …

Social defeat stress induces an anxiety-like outcome in male prairie voles (Microtus ochrogaster)

M Rodriguez, A Themann, DE Calvo… - Oxford Open …, 2024 - academic.oup.com
Anxiety-related illnesses constitute one of the leading causes of disability across the globe.
Consequently, the need for validated preclinical models to uncover the etiology of anxiety …

The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders

LB Teal, SM Ingram, M Bubser, E McClure… - Drug Development in …, 2023 - Springer
Historically, animal models have been routinely used in the characterization of novel
chemical entities (NCEs) for various psychiatric disorders. Animal models have been …

Adolescent fluoxetine exposure increases ERK-related signaling within the prefrontal cortex of adult male Sprague-Dawley rats

A Themann, M Rodriguez… - Oxford open …, 2022 - academic.oup.com
There has been a disproportionate increase in fluoxetine (FLX) prescription rates within the
juvenile population. Thus, we evaluated how adolescent FLX exposure alters expression …

Sex-dependent effects of pair bond interruption on anxiety-and depression-like behaviors in adult mandarin voles

Y Feng, Y Yang, Y Wang, X Lv, X Zhang, Y Wang… - Behavioural …, 2021 - Elsevier
Stable and positive social bonds are pretty vital to the development of animals. Instability
and disruptions of social bonds, such as maternal separation and social isolation, always …