Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and
cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the …

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the
treatment of different cancers and other diseases. However, no clinically approved drugs for …

The fifth edition of the World Health Organization Classification of Haematolymphoid
Tumours (WHO‐HAEM5) is the product of an evidence‐based evolution of the revised fourth …

The clinical and immunological impact of B‐cell depletion in the context of coronavirus
disease 2019 (COVID‐19) is unclear. We conducted a prospectively planned analysis of …

Follicular lymphoma (FL) represents a heterogeneous disease both clinically and
biologically. The pathognomonic t (14; 18) translocation can no longer be thought of as the …

Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …

The variable clinical course of follicular lymphoma (FL) is determined by the molecular
heterogeneity of tumor cells and complex interactions within the tumor microenvironment …

Follicular lymphoma (FL) is a neoplasm derived from germinal center B cells, composed of
centrocytes and centroblasts, with at least a focal follicular growth pattern. The t (14; 18) …