Nanoparticle toxicology

W Yang, L Wang, EM Mettenbrink… - Annual Review of …, 2021 - annualreviews.org
Nanoparticles from natural and anthropogenic sources are abundant in the environment,
thus human exposure to nanoparticles is inevitable. Due to this constant exposure, it is …

Development of ionic liquid-coated PLGA nanoparticles for applications in intravenous drug delivery

CM Hamadani, GS Dasanayake, ME Gorniak… - Nature …, 2023 - nature.com
Polymeric nanoparticles (NPs) are a promising platform for medical applications in drug
delivery. However, their use as drug carriers is limited by biological (eg, immunological) …

Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity

S Chen, Y Zhong, W Fan, J Xiang, G Wang… - Nature Biomedical …, 2021 - nature.com
Effective anticancer nanomedicines need to exhibit prolonged circulation in blood, to
extravasate and accumulate in tumours, and to be taken up by tumour cells. These …

Multistate and functional protein design using RoseTTAFold sequence space diffusion

SL Lisanza, JM Gershon, SWK Tipps, JN Sims… - Nature …, 2024 - nature.com
Protein denoising diffusion probabilistic models are used for the de novo generation of
protein backbones but are limited in their ability to guide generation of proteins with …

Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

SK Bedingfield, JM Colazo, F Yu, DD Liu… - Nature biomedical …, 2021 - nature.com
The progression of osteoarthritis is associated with inflammation triggered by the enzymatic
degradation of extracellular matrix in injured cartilage. Here we show that a locally injected …

Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles

LI Selby, CM Cortez‐Jugo, GK Such… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Using nanoparticles to deliver drugs to cells has the potential to revolutionize the treatment
of many diseases, including HIV, cancer, and diabetes. One of the major challenges facing …

Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy

Y Lu, K Huntoon, DY Lee, Y Wang, JH Ha, Y Qie… - Nature …, 2022 - nature.com
Solid tumours display a limited response to immunotherapies. By contrast, haematological
malignancies exhibit significantly higher response rates to immunotherapies as compared …

Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part

L Lockowandt, J Pinela, CL Roriz, C Pereira… - Industrial Crops and …, 2019 - Elsevier
Cornflower is a flowering weed and ornamental plant whose blue flowers have been used
for food, decorative and colouring purposes. In this study, the upper (edible flowers) and …

Chitosan-collagen-hydroxyapatite membranes for tissue engineering

J Becerra, M Rodriguez, D Leal, K Noris-Suarez… - Journal of Materials …, 2022 - Springer
Tissue engineering is growing in developing new technologies focused on providing
effective solutions to degenerative pathologies that affect different types of connective …

Biogenic synthesis and characterization of antimicrobial and antiparasitic zinc oxide (ZnO) nanoparticles using aqueous extracts of the Himalayan Columbine …

H Jan, M Shah, H Usman, MA Khan, M Zia… - Frontiers in …, 2020 - frontiersin.org
Herein, we report a facile, economic, one-pot green synthesis of zinc oxide nanoparticles
(ZnO-NPs) for diverse biomedical applications. In the study, ZnO-NPs were synthesized …