Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

Brain is a vital organ of the human body which performs very important functions such as
analysis, processing, coordination, and execution of electrical signals. For this purpose, it …

Cholesterol is an essential component for neuronal physiology not only during development
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently
affecting over 5 million Americans with projections expected to rise as the population ages …

Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid,
and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal …

Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein
receptors and, through its interaction with these receptors, participates in the transport of …

Carbon monoxide (CO) poisoning is common in modern society, resulting in significant
morbidity and mortality in the United States annually. Over the past two decades, sufficient …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein
metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary …