Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

Fever is a complex physiologic response triggered by infectious or aseptic stimuli.
Elevations in body temperature occur when concentrations of prostaglandin E2 (PGE2) …

Rationale: Fever control may improve vascular tone and decrease oxygen consumption, but
fever may contribute to combat infection. Objectives: To determine whether fever control by …

The regulation of brain temperature is largely dependent on the metabolic activity of brain
tissue and remains complex. In intensive care clinical practice, the continuous monitoring of …

This paper reviews the function, brain mechanisms and pharmacology of stress-induced
hyperthermia (SIH) in a broad context. Hyperthermia itself is induced by all stressful stimuli …

Systemic inflammation-associated syndromes (eg, sepsis and septic shock) often have high
mortality and remain a challenge in emergency medicine. Systemic inflammation is usually …

Fever has been recognized as an important symptom of disease since ancient times. For
many years, fever was treated as a putative life-threatening phenomenon. More recently, it …

Sepsis and systemic inflammatory response syndrome (SIRS) are associated with an
exacerbated production of both pro-and anti-inflammatory mediators that are mainly …

The formation of neutrophil extracellular traps (NETs) is a newly described phenomenon that
increases the bacteria-killing ability and the inflammatory response of neutrophils. Because …