Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults
EM Stoffel, CC Murphy - Gastroenterology, 2020 - Elsevier
In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …
The genetics of human ageing
The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
[PDF][PDF] Genome-wide modeling of polygenic risk score in colorectal cancer risk
M Thomas, LC Sakoda, M Hoffmeister… - The American journal of …, 2020 - cell.com
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying
individuals at low and high risk of developing CRC, as they can then be offered targeted …
individuals at low and high risk of developing CRC, as they can then be offered targeted …
[HTML][HTML] Update on genetic predisposition to colorectal cancer and polyposis
The present article summarizes recent developments in the characterization of genetic
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …
Cumulative burden of colorectal cancer–associated genetic variants is more strongly associated with early-onset vs late-onset cancer
Background & Aims Early-onset colorectal cancer (CRC, in persons younger than 50 years
old) is increasing in incidence; yet, in the absence of a family history of CRC, this population …
old) is increasing in incidence; yet, in the absence of a family history of CRC, this population …
[HTML][HTML] Delphi initiative for early-onset colorectal cancer (DIRECt) international management guidelines
GM Cavestro, A Mannucci, F Balaguer… - Clinical …, 2023 - Elsevier
Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …
according to guidelines that are not age-specific. A multidisciplinary international group …
Large-scale genome-wide association study of East Asians identifies loci associated with risk for colorectal cancer
Y Lu, SS Kweon, C Tanikawa, WH Jia, YB Xiang, Q Cai… - Gastroenterology, 2019 - Elsevier
Background & Aims Genome-wide association studies (GWASs) have associated
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …
Risk stratification for early-onset colorectal cancer using a combination of genetic and environmental risk scores: an international multi-center study
Background The incidence of colorectal cancer (CRC) among individuals aged younger
than 50 years has been increasing. As screening guidelines lower the recommended age of …
than 50 years has been increasing. As screening guidelines lower the recommended age of …
[HTML][HTML] Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …