The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most
important advance in sleep research and sleep medicine since the discovery of rapid eye …

Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of the structural and functional integrity of the central and peripheral nervous …

The brain is one of the most complex organs in the body, which emerges from a relatively
simple set of basic 'building blocks' during early development according to complex cellular …

No biological system or structure is likely to be perfectly symmetrical, or have identical right
and left forms. This review explores the evidence for eye and visual pathway asymmetry, in …

As three-dimensional “organ-like” aggregates, human cortical organoids have emerged as
powerful models for studying human brain evolution and brain disorders with unique …

Abstract Three‐dimensional (3D) cerebral cortical organoids are popular in vitro cellular
model systems widely used to study human brain development and disease, compared to …

It remains largely unknown how Zika virus (ZIKV) infection causes severe microcephaly in
human newborns. We examined an Asian lineage ZIKV, SZ01, which similarly infected and …

The neuroectoderm is patterned along a rostral-caudal axis in response to localized factors
in the embryo, but exactly how these factors act as positional information for this patterning is …

Human induced pluripotent stem (iPS) cells have the potential to give rise to a new era in
Parkinson's disease (PD) research. As a unique source of midbrain dopaminergic (DA) …

Aging is associated with cognitive decline and increased vulnerability to neurodegenerative
diseases. The progressive extension of the average human lifespan is bound to lead to a …