Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …

The universality of calcium as an intracellular messenger depends on its enormous
versatility. Cells have a calcium signalling toolkit with many components that can be mixed …

When the history of signal transduction is written in 2100, what will be remembered of the
exciting advances that occurred in the latter half of the twentieth century? Everyone will …

Fluorescent probes are one of the cornerstones of real-time imaging of live cells and a
powerful tool for cell biologists. They provide high sensitivity and great versatility while …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

During the last 100 years, cell signaling has evolved into a common mechanism for most
physiological processes across systems. Although the majority of cell signaling principles …

Visual arrestin, βarrestin1, and βarrestin2 comprise a family of intracellular proteins that
desensitize G protein-coupled receptors (GPCRs). In addition, βarrestin1 and βarrestin2 …

Abstract Background Calcium (Ca 2+) oscillations are ubiquitous signals present in all cells
that provide efficient means to transmit intracellular biological information. Either …

In most instances, the growth of solid tumors occurs in constrained environments and
requires a competition for space. A mechanical crosstalk can arise from this competition. In …