One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …

The primary function of the gut is to procure nutrients. Synchronized mechanical activities
underlie nearly all its endeavours. Coordination of mechanical activities depends on …

Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the
gastrointestinal tract, but the signaling processes that link immune activation with visceral …

Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are
well-known complications affecting patients undergoing intestinal surgery. GI symptoms …

Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …

Highlights•Enteric glial cells (EGCs) are required for maintenance of gut tissue
homeostasis.•GFAP+ EGCs regulate the health of the intestinal epithelial barrier.•EGCs …

The epithelial lining of the gastrointestinal tract serves as the interface for digestion and
absorption of nutrients and water and as a defensive barrier. The defensive functions of the …

S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …