Ageing, metabolism and the intestine

MC Funk, J Zhou, M Boutros - EMBO reports, 2020 - embopress.org
The intestinal epithelium serves as a dynamic barrier to the environment and integrates a
variety of signals, including those from metabolites, commensal microbiota, immune …

Orchestration of MUC2—The key regulatory target of gut barrier and homeostasis: A review

Y Liu, Z Yu, L Zhu, S Ma, Y Luo, H Liang, Q Liu… - International Journal of …, 2023 - Elsevier
The gut mucosa of human is covered by mucus, functioning as a crucial defense line for the
intestine against external stimuli and pathogens. Mucin2 (MUC2) is a subtype of secretory …

[HTML][HTML] Secretory sorcery: paneth cell control of intestinal repair and homeostasis

P Cray, BJ Sheahan, CM Dekaney - Cellular and Molecular …, 2021 - Elsevier
Paneth cells are professional secretory cells that, classically, play a role in the innate
immune system by secreting antimicrobial factors into the lumen to control enteric bacteria …

The intestinal epithelium–fluid fate and rigid structure from crypt bottom to villus tip

V Bonis, C Rossell, H Gehart - Frontiers in cell and developmental …, 2021 - frontiersin.org
The single-layered, simple epithelium of the gastro-intestinal tract controls nutrient uptake,
coordinates our metabolism and shields us from pathogens. Despite its seemingly simple …

Plasticity of Paneth cells and their ability to regulate intestinal stem cells

X Mei, M Gu, M Li - Stem cell research & therapy, 2020 - Springer
Paneth cells (PCs) are located at the bottom of small intestinal crypts and play an important
role in maintaining the stability of the intestinal tract. Previous studies reported on how PCs …

[HTML][HTML] LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases

Y Zhang, Q Meng, Q Sun, ZX Xu, H Zhou, Y Wang - Molecular Metabolism, 2021 - Elsevier
Abstract Background Live kinase B1 (LKB1) is a tumor suppressor, which is mutated in
Peutz-Jeghers syndrome (PJS) and in a variety of cancers. Lkb1 encodes serine-threonine …

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice

A Aliluev, S Tritschler, M Sterr, L Oppenländer… - Nature …, 2021 - nature.com
Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic
energy imbalance, which causes obesity and an increased risk of type 2 diabetes and …

Mitochondrial metabolism in the intestinal stem cell niche—sensing and signaling in health and disease

E Urbauer, E Rath, D Haller - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Mitochondrial metabolism, dynamics, and stress responses in the intestinal stem cell niche
play a pivotal role in regulating intestinal epithelial cell homeostasis, including self-renewal …

Molecular regulation after mucosal injury and regeneration in ulcerative colitis

L Zheng, SL Duan, XL Wen, YC Dai - Frontiers in Molecular …, 2022 - frontiersin.org
Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with a complex etiology.
Intestinal mucosal injury is an important pathological change in individuals with UC. Leucine …

[HTML][HTML] Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients

HA McCauley, AM Riedman, JR Enriquez… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims The intestinal stem cell niche is exquisitely sensitive to changes in diet,
with high-fat diet, caloric restriction, and fasting resulting in altered crypt metabolism and …