Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …

A significant body of work has investigated the effects of acute exercise, defined as a single
bout of physical activity, on mood and cognitive functions in humans. Several excellent …

Exercise is a non-pharmacological strategy to mitigate the deleterious effects of aging on
brain health. However, a large amount of variation exists in its efficacy. Sex of participants …

The coordination of nutrient sensing, delivery, uptake and utilization is essential for
maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the
combined presence of amyloid and tau, but researchers are gradually moving away from the …