Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
A long look at short prokaryotic Argonautes
Argonaute proteins (Agos) use small 15–30 nucleotide-long guides to bind and/or cleave
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …
[HTML][HTML] An expanded arsenal of immune systems that protect bacteria from phages
Bacterial anti-phage systems are frequently clustered in microbial genomes, forming
defense islands. This property enabled the recent discovery of multiple defense systems …
defense islands. This property enabled the recent discovery of multiple defense systems …
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion
M Zaremba, D Dakineviciene, E Golovinas… - Nature …, 2022 - nature.com
Argonaute (Ago) proteins are found in all three domains of life. The so-called long Agos are
composed of four major domains (N, PAZ, MID and PIWI) and contribute to RNA silencing in …
composed of four major domains (N, PAZ, MID and PIWI) and contribute to RNA silencing in …
The evolutionary success of regulated cell death in bacterial immunity
Highlights•Many antiphage systems trigger regulated death of the infected cell.•Regulated
cell death protects the nearby population from the spread of infection.•Over 70% of …
cell death protects the nearby population from the spread of infection.•Over 70% of …
Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products
AM Bayless, S Chen, SC Ogden, X Xu, JD Sidda… - Science …, 2023 - science.org
Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In
plants and bacteria, TIR domains are often enzymes that produce isomers of cyclic …
plants and bacteria, TIR domains are often enzymes that produce isomers of cyclic …
Activation mechanism of a short argonaute-TIR prokaryotic immune system
D Ni, X Lu, H Stahlberg, B Ekundayo - Science Advances, 2023 - science.org
Short prokaryotic argonaute (pAgo) and toll/interleukin-1 receptor/resistance protein (TIR)–
analog of PAZ (APAZ) form a heterodimeric SPARTA complex that provides immunity to its …
analog of PAZ (APAZ) form a heterodimeric SPARTA complex that provides immunity to its …
Oligomerization-mediated activation of a short prokaryotic Argonaute
Although eukaryotic and long prokaryotic Argonaute proteins (pAgos) cleave nucleic acids,
some short pAgos lack nuclease activity and hydrolyse NAD (P)+ to induce bacterial cell …
some short pAgos lack nuclease activity and hydrolyse NAD (P)+ to induce bacterial cell …
[HTML][HTML] Argonaute proteins confer immunity in all domains of life
PB Ugarte, P Barendse, DC Swarts - Current opinion in microbiology, 2023 - Elsevier
Both eukaryotes and prokaryotes (archaea and bacteria) encode an arsenal of immune
systems that protect the host against mobile genetic elements (MGEs) including viruses …
systems that protect the host against mobile genetic elements (MGEs) including viruses …