Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Background Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive
treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the …

Background Artemisinin-based combinations therapy (ACT) is the current frontline curative
therapy for uncomplicated malaria in Burkina Faso. Sulfadoxine-pyrimethamine (SP) is used …

Intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-
SP) is used to prevent malaria and associated unfavorable maternal and foetal outcomes in …

Intermittent preventive treatment in pregnancy with sulphadoxine− pyrimethamine (IPTp-SP)
is one of the main strategies for protecting pregnant women, fetus, and their new-born …

Background: The spread of drug resistance has seriously impacted the effective treatment of
infection with the malaria parasite, Plasmodium falciparum. Continuous monitoring of …

In the present study, we have explored the anti-malarial potential of epoxyazadiradione, the
natural entity extracted from the neem seed oil and its chemical derivatives, against …

Antimalarial resistance is an inevitable feature of control efforts and a key threat to achieving
malaria elimination. Plasmodium falciparum, the deadliest of several species causing …

Purpose Antimalarial drug resistance is one of the major challenges in global efforts to
control and eliminate malaria. In 2006, sulfadoxine-pyrimethamine (SP) replaced with …

Genetic changes conferring drug resistance are generally believed to impose fitness costs to
pathogens in the absence of the drug. However, the fitness of resistant parasites against …