Cystic fibrosis: insight into CFTR pathophysiology and pharmacotherapy
Cystic fibrosis is the most common life-threatening recessively inherited disease in
Caucasians. Due to early provision of care in specialized reference centers and more …
Caucasians. Due to early provision of care in specialized reference centers and more …
[HTML][HTML] Bacterial overgrowth, dysbiosis, inflammation, and dysmotility in the Cystic Fibrosis intestine
J Dorsey, T Gonska - Journal of Cystic Fibrosis, 2017 - Elsevier
Abstract Gastrointestinal disease in Cystic Fibrosis (CF) is caused by defective chloride and
bicarbonate transport in intestinal cells leading to reduced intraluminal fluidity, increased …
bicarbonate transport in intestinal cells leading to reduced intraluminal fluidity, increased …
Multicenter prospective study showing a high gastrointestinal symptom burden in cystic fibrosis
Background and aims People with cystic fibrosis (PwCF) suffer from gastrointestinal (GI)
symptoms affecting their quality of life (QOL). Despite the relevance of GI symptoms to the …
symptoms affecting their quality of life (QOL). Despite the relevance of GI symptoms to the …
Gastrointestinal complications of cystic fibrosis
D Gelfond, D Borowitz - Clinical Gastroenterology and Hepatology, 2013 - Elsevier
The cystic fibrosis transmembrane regulator protein (CFTR) is an ion channel in the apical
surface of epithelial membranes that regulates other ion channels. Dysfunction of CFTR …
surface of epithelial membranes that regulates other ion channels. Dysfunction of CFTR …
The PACSYM questionnaire for chronic constipation: defining the minimal important difference
Y Yiannakou, J Tack, H Piessevaux… - Alimentary …, 2017 - Wiley Online Library
Summary Background The Patient Assessment of ConstipationSymptoms (PACSYM)
questionnaire is frequently used in clinical trials of constipation. However, the threshold for …
questionnaire is frequently used in clinical trials of constipation. However, the threshold for …
[HTML][HTML] Cystic fibrosis & disorders of the large intestine: DIOS, constipation, and colorectal cancer
JM Abraham, CJ Taylor - Journal of Cystic Fibrosis, 2017 - Elsevier
Abstract Since 1966 when the Cystic Fibrosis Foundation Patient Registry (CFFPR) was
founded, clinicians have witnessed significant advances in both the quality and quantity of …
founded, clinicians have witnessed significant advances in both the quality and quantity of …
Gastrointestinal disorders in cystic fibrosis
DN Assis, SD Freedman - Clinics in chest medicine, 2016 - chestmed.theclinics.com
Gastrointestinal (GI) abnormalities are integral to the clinical manifestations of cystic fibrosis
(CF). Indeed, the very first publication of CF in 1938 reported pediatric steatorrhea with …
(CF). Indeed, the very first publication of CF in 1938 reported pediatric steatorrhea with …
Inhibition of Na+/H+ exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulatordeficient and F508del mutant …
Q Tan, G di Stefano, X Tan, X Renjie… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Constipation and intestinal obstructive episodes are major health
problems in cystic fibrosis (CF) patients. Three FDAapproved drugs against constipation …
problems in cystic fibrosis (CF) patients. Three FDAapproved drugs against constipation …
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis
J Green, FJ Gilchrist, W Carroll - Cochrane Database of …, 2018 - cochranelibrary.com
Background Cystic fibrosis (CF) is the most common, lifelimiting, genetically inherited
disease. It affects multiple organs, particularly the respiratory system. However …
disease. It affects multiple organs, particularly the respiratory system. However …
Lubiprostone in constipation: clinical evidence and place in therapy
N Wilson, R Schey - Therapeutic advances in chronic …, 2015 - journals.sagepub.com
Constipation is one of the most common function bowel disorders encountered by primary
care providers and gastroenterologists. Disorders of chronic constipation, including irritable …
care providers and gastroenterologists. Disorders of chronic constipation, including irritable …