Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

When blood vessels are cut, the forces in the bloodstream increase and change character.
The dark side of these forces causes hemorrhage and death. However, von Willebrand …

SARS-CoV-2 has been spreading around the world for the past year. Recently, several
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …

TCR-signaling strength generally correlates with peptide-MHC binding affinity; however,
exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high …

Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von
Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and …

Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα
during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis …

Intravascular blood clots form in an environment in which hydrodynamic forces dominate
and in which fluid-mediated transport is the primary means of moving material. The clotting …

Single-molecule magnetic tweezers deliver magnetic force and torque to single target
molecules, permitting the study of dynamic changes in biomolecular structures and their …