Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …

SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …

Emerging data indicate that complement and neutrophils contribute to the maladaptive
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …

Across the world's coronavirus disease 2019 (COVID-19) hot spots, the need to streamline
patient diagnosis and management has become more pressing than ever. As one of the …

Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic is hypothesized to be driven by an overreacting innate immune response, where …

Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …