CYP51 as drug targets for fungi and protozoan parasites: past, present and future

GI Lepesheva, L Friggeri, MR Waterman - Parasitology, 2018 - cambridge.org
The efficiency of treatment of human infections with the unicellular eukaryotic pathogens
such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates …

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol …

TY Hargrove, L Friggeri, Z Wawrzak, A Qi… - Journal of Biological …, 2017 - ASBMB
With some advances in modern medicine (such as cancer chemotherapy, broad exposure to
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …

Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2021

BW Teh, DK Yeoh, GM Haeusler… - Internal Medicine …, 2021 - Wiley Online Library
Antifungal prophylaxis can reduce morbidity and mortality from invasive fungal disease
(IFD). However, its use needs to be optimised and appropriately targeted to patients at …

Contemporary management and clinical outcomes of mucormycosis: a systematic review and meta-analysis of case reports

W Jeong, C Keighley, R Wolfe, WL Lee… - International journal of …, 2019 - Elsevier
With the advent of newer antifungals, optimum treatment of mucormycosis remains to be fully
elucidated. This study systematically evaluated the contemporary management and …

Clinical features and treatment progress of invasive mucormycosis in patients with hematological malignancies

N Yang, L Zhang, S Feng - Journal of Fungi, 2023 - mdpi.com
The incidence rate of invasive mucormycosis (IM) in patients with hematological
malignancies (HMs) is increasing year by year, ranging from 0.07% to 4.29%, and the …

Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease

OA Cornely, MN Robertson, S Haider… - Journal of …, 2017 - academic.oup.com
Objectives A two-part (Phase 1B/3), sequential, open-label, multicentre study evaluated the
pharmacokinetics (PK) and safety of intravenous (iv) posaconazole given as antifungal …

Choice and duration of antifungal prophylaxis and treatment in high-risk haematology patients

J Coussement, J Lindsay, BW Teh… - Current Opinion in …, 2021 - journals.lww.com
Prophylaxis and treatment of invasive fungal diseases in high-risk haematology patients is a
rapidly evolving field. Critical clinical questions remain unanswered, especially regarding …

Common drug-drug interactions in antifungal treatments for superficial fungal infections

AK Gupta, SG Versteeg, NH Shear - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Antifungal agents can be co-administered alongside several other medications
for a variety of reasons such as the presence of comorbidities. Pharmacodynamic …

Invasive fungal infections in high-risk patients: report from TIMM-8 2017

L Pagano, S Mayor - 2018 - Taylor & Francis
Trends in Medical Mycology (TIMM) is the biennial meeting of the Infectious Disease Group
of the European Organisation for Research and Treatment of Cancer (EORTC) and the …

An update on the safety and interactions of antifungal drugs in stem cell transplant recipients

C Girmenia, AP Iori - Expert Opinion on Drug Safety, 2017 - Taylor & Francis
ABSTRACT Introduction: Invasive fungal diseases (IFDs) are a major cause of morbidity and
mortality in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) …