CYP51 as drug targets for fungi and protozoan parasites: past, present and future
GI Lepesheva, L Friggeri, MR Waterman - Parasitology, 2018 - cambridge.org
The efficiency of treatment of human infections with the unicellular eukaryotic pathogens
such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates …
such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates …
Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol …
TY Hargrove, L Friggeri, Z Wawrzak, A Qi… - Journal of Biological …, 2017 - ASBMB
With some advances in modern medicine (such as cancer chemotherapy, broad exposure to
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …
Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2021
Antifungal prophylaxis can reduce morbidity and mortality from invasive fungal disease
(IFD). However, its use needs to be optimised and appropriately targeted to patients at …
(IFD). However, its use needs to be optimised and appropriately targeted to patients at …
Contemporary management and clinical outcomes of mucormycosis: a systematic review and meta-analysis of case reports
With the advent of newer antifungals, optimum treatment of mucormycosis remains to be fully
elucidated. This study systematically evaluated the contemporary management and …
elucidated. This study systematically evaluated the contemporary management and …
Clinical features and treatment progress of invasive mucormycosis in patients with hematological malignancies
N Yang, L Zhang, S Feng - Journal of Fungi, 2023 - mdpi.com
The incidence rate of invasive mucormycosis (IM) in patients with hematological
malignancies (HMs) is increasing year by year, ranging from 0.07% to 4.29%, and the …
malignancies (HMs) is increasing year by year, ranging from 0.07% to 4.29%, and the …
Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease
OA Cornely, MN Robertson, S Haider… - Journal of …, 2017 - academic.oup.com
Objectives A two-part (Phase 1B/3), sequential, open-label, multicentre study evaluated the
pharmacokinetics (PK) and safety of intravenous (iv) posaconazole given as antifungal …
pharmacokinetics (PK) and safety of intravenous (iv) posaconazole given as antifungal …
Choice and duration of antifungal prophylaxis and treatment in high-risk haematology patients
Prophylaxis and treatment of invasive fungal diseases in high-risk haematology patients is a
rapidly evolving field. Critical clinical questions remain unanswered, especially regarding …
rapidly evolving field. Critical clinical questions remain unanswered, especially regarding …
Common drug-drug interactions in antifungal treatments for superficial fungal infections
AK Gupta, SG Versteeg, NH Shear - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Antifungal agents can be co-administered alongside several other medications
for a variety of reasons such as the presence of comorbidities. Pharmacodynamic …
for a variety of reasons such as the presence of comorbidities. Pharmacodynamic …
Invasive fungal infections in high-risk patients: report from TIMM-8 2017
L Pagano, S Mayor - 2018 - Taylor & Francis
Trends in Medical Mycology (TIMM) is the biennial meeting of the Infectious Disease Group
of the European Organisation for Research and Treatment of Cancer (EORTC) and the …
of the European Organisation for Research and Treatment of Cancer (EORTC) and the …
An update on the safety and interactions of antifungal drugs in stem cell transplant recipients
C Girmenia, AP Iori - Expert Opinion on Drug Safety, 2017 - Taylor & Francis
ABSTRACT Introduction: Invasive fungal diseases (IFDs) are a major cause of morbidity and
mortality in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) …
mortality in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) …